GHK-Cu

GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-histidyl-lysine) whose levels in the body decline with age, and it plays a role in skin and connective tissue remodeling.

In fibroblast culture studies, GHK-Cu stimulates production of collagen and glycosaminoglycans and modulates matrix metalloproteinases alongside their natural tissue inhibitors, favoring orderly turnover of the skin matrix rather than simple buildup or breakdown.

Animal wound models have shown faster tissue closure with topical GHK-Cu application, and gene expression analyses link the peptide to hundreds of genes tied to tissue repair and antioxidant defense, which continues to drive research into skin remodeling and wound healing.