hGH Fragment

hGH Fragment 176-191 is the C-terminal region of human growth hormone, isolated because it retains the hormone’s fat-metabolizing activity without binding the GH receptor or affecting blood sugar or tissue growth.

In obese mice, chronic treatment with the fragment reduced body weight gain and increased fat oxidation, effects linked to increased expression of the beta-3 adrenergic receptor, the primary lipolytic receptor in fat tissue.

Because it separates lipolysis from the growth and metabolic effects of full-length GH, it remains a focus of research into fat-specific metabolic pathways.